Bluefish: A Relational Framework for Graphic Representations

Complex graphic representations -- such as annotated visualizations, molecular structure diagrams, or Euclidean geometry -- convey information through overlapping perceptual relations. To author such representations, users are forced to use rigid, purpose-built tools with limited flexibility and expressiveness. User interface (UI) frameworks provide only limited relief as their tree-based models are a poor fit for expressing overlaps. We present Bluefish, a diagramming framework that extends UI architectures to support overlapping perceptual relations. Bluefish graphics are instantiated as relational scenegraphs: hierarchical data structures augmented with adjacency relations. Authors specify these relations with scoped references to components found elsewhere in the scenegraph. For layout, Bluefish lazily materializes necessary coordinate transformations. We demonstrate that Bluefish enables authoring graphic representations across a diverse range of domains while preserving the compositional and abstractional affordances of traditional UI frameworks. Moreover, we show how relational scenegraphs capture previously latent semantics that can later be retargeted (e.g., for screen reader accessibility).Comment: 27 pages, 14 figure

Longitudinal deprivation trajectories and risk of cardiovascular disease in New Zealand

We used longitudinal information on area deprivation status to explore the relationship between residential-deprivation mobility and Cardiovascular Disease (CVD). Data from 2,418,397 individuals who were: enrolled in any Primary Health Organisation within New Zealand (NZ) during at least 1 of 34 calendar quarters between 1st January 2006 and 30th June 2014; aged between 30 and 84 years (inclusive) at the start of the study period; had no prior history of CVD; and had recorded address information were analysed. Including a novel trajectory analysis, our findings suggest that movers are healthier than stayers. The deprivation characteristics of the move have a larger impact on the relative risk of CVD for younger movers than for older movers. For older movers any kind of move is associated with a decreased risk of CVD

Design constraints and higher temperature intermetallic bond coatings

Bond coat interlayers in thermal barrier coating (TBC) systems must perform reliably in the complex thermal, chemical and mechanical environment of the turbine engine. To achieve higher temperatures and /or longer cyclic lives, a spectrum of intrinsic failure modes must be suppressed. Failure may occur at the bond coat – thermally grown oxide (TGO) interface, at the TGO-TBC interface or by oxidation-enhanced propagation of cracks from the coating into the substrate. Models for the failure processes suggest that bond coatings should possess improved high temperature strength (creep resistance), low oxide growth stresses and high interfacial toughnesses. Oxide growth stresses have been measured across a spectrum of bond coat compositions. A new femtosecond laser-based approach to measuring interfacial toughness will be discussed. Finally, the behavior of multilayered intermetallic coatings designed to be thermodynamically compatible with the superalloy substrate under cyclic oxidation conditions will be presented

Finding enthymemes in real-world texts: A feasibility study

Enthymeme reconstruction, i.e. the task of reformulating arguments with missing propositions, is an exciting task at the borderline of text understanding and argument interpretation. However, there is some doubt in the community about the feasibility of this task due to the wide range of possible reformulations that are open to humans. We therefore believe that research on how to define an objective ground truth for these tasks is necessary before any work on the automatic reconstruction can begin. Here, we present a feasibility study for the task of finding and expanding enthymemes involving a fortiori arguments in real-world texts, and we show that given a sufficiently strict reformulation of the human annotation task, substantial agreement can be achieved. We split the task into three sub-tasks: 1. deciding whether a candidate text span really represents an enthymematic argument, 2. classifying the type of a fortiori argument concerned and 3. describing the missing premise in natural language. In a case study involving the two authors of this paper as annotators, we test a specific type of a fortiori arguments, the let alone construction, for its suitability for reaching high agreement in all three stages of the task. We also discuss pragmatic effects of let alone and how they relate to argumentation theory

How the mass media report social statistics: A case study concerning research on end-of-life decisions

This is the post-print version of the final paper published in Social Science & Medicine. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. Copyright @ 2010 Elsevier B.V.The issue of whether it is right to be concerned about the accuracy with which mass media report social scientific research is explored through a detailed case study of media reporting of two surveys of UK doctors' end-of-life decision-making. Data include press releases, emails and field notes taken during periods of media interest supplemented by a collection of print and broadcast media reports. The case study contributes to existing knowledge about the ways in which mass media establish, exaggerate and otherwise distort the meaning of statistical findings. Journalists ignored findings that did not fit into existing media interest in the 'assisted dying' story and were subject to pressure from interest groups concerned to promote their own interpretations and viewpoints. Rogue statistics mutated as they were set loose from their original research report context and were 'laundered' as they passed from one media report to another. Yet media accounts of the research, fuelling an already heated public debate about ethical issues in end-of-life care, arguably acted as a conduit for introducing new considerations into this debate, such as the role played by sedation at the end of life, the extent to which euthanasia is practiced outside the law, and the extent of medical opposition to the legalisation of assisted dying. The expectation that accuracy and comprehensiveness should be the sole criteria for judging journalists' reports is, finally, considered to be unrealistic and it is argued that social scientists need to understand and adapted to the conditions under which mass media reporting operates if they are to succeed in introducing the findings of social research into public debates.The Nuffield Foundation, the National Council for Palliative Care, Age Concern, the Motor Neurone Disease Association, the Multiple Sclerosis Society, Help the Hospices, Macmillan Cancer Support, and Sue Ryder Care

Ageing-induced changes in the redox status of peripheral motor nerves imply an effect on redox signalling rather than oxidative damage

Ageing is associated with loss of skeletal muscle fibres, atrophy of the remaining fibres and weakness. These changes in muscle are accompanied by disruption of motor neurons and neuromuscular junctions although the direct relationship between the nerve and muscle degeneration is not understood. Oxidative changes have been implicated in the mechanisms leading to age-related loss of muscle mass and in degeneration of the central nervous system, but little is known about age-related changes in oxidation in specific peripheral nerves that supply muscles that are affected by ageing. We have therefore examined the sciatic nerve of old mice at an age when loss of tibialis anterior muscle mass and function is apparent. Sciatic nerve from old mice did not show a gross increase in oxidative damage, but electron paramagnetic resonance (EPR) studies indicated an increase in the activity of superoxide and/or peroxynitrite in the nerves of old mice at rest that was further exacerbated by electrical stimulation of the nerve to activate muscle contractions. Proteomic analyses indicated that specific redox-sensitive proteins are increased in content in the nerves of old mice that may reflect an adaptation to regulate the increased superoxide/peroxynitrite and maintain redox homoeostasis. Analysis of redox active cysteines showed some increase in reversible oxidation in specific proteins in nerves of old mice, but this was not universally seen across all redox-active cysteines. Detailed analysis of the redox-active cysteine in one protein in the nerve of old mice that is key to redox signalling (Peroxiredoxin 6, Cys 47) showed a minor increase in reversible oxidation that would be compatible with a change in its redox signalling function. In conclusion, the data presented indicate that sciatic nerve from old mice does not show a gross increase in oxidative damage similar to that seen in the TA and other muscles that it innervates. Our results indicate an adaptation to increased oxidation with minor changes in the oxidation of key cysteines that may contribute to defective redox signalling in the nerve

Maternal super-obesity and perinatal outcomes in Australia: A national population-based cohort study

Background: Super-obesity is associated with significantly elevated rates of obstetric complications, adverse perinatal outcomes and interventions. The purpose of this study was to determine the prevalence, risk factors, management and perinatal outcomes of super-obese women giving birth in Australia. Methods: A national population-based cohort study. Super-obese pregnant women (body mass index (BMI) >50 kg/m2 or weight >140 kg) who gave birth between January 1 and October 31, 2010 and a comparison cohort were identified using the Australasian Maternity Outcomes Surveillance System (AMOSS). Outcomes included maternal and perinatal morbidity and mortality. Prevalence estimates calculated with 95 % confidence intervals (CIs). Adjusted odds ratios (ORs) were calculated using multivariable logistic regression. Results: 370 super-obese women with a median BMI of 52.8 kg/m2 (range 40.9–79.9 kg/m2) and prevalence of 2.1 per 1 000 women giving birth (95 % CI: 1.96–2.40). Super-obese women were significantly more likely to be public patients (96.2 %), smoke (23.8 %) and be socio-economically disadvantaged (36.2 %). Compared with other women, super-obese women had a significantly higher risk for obstetric (adjusted odds ratio (AOR) 2.42, 95 % CI: 1.77–3.29) and medical (AOR: 2.89, 95 % CI: 2.64–4.11) complications during pregnancy, birth by caesarean section (51.6 %) and admission to special care (HDU/ICU) (6.2 %). The 372 babies born to 365 super-obese women with outcomes known had significantly higher rates of birthweight ≥4500 g (AOR 19.94, 95 % CI: 6.81–58.36), hospital transfer (AOR 3.81, 95 % CI: 1.93–7.55) and admission to Neonatal Intensive Care Unit (NICU) (AOR 1.83, 95 % CI: 1.27–2.65) compared to babies of the comparison group, but not prematurity (10.5 % versus 9.2 %) or perinatal mortality (11.0 (95 % CI: 4.3–28.0) versus 6.6 (95 % CI: 2.6- 16.8) per 1 000 singleton births). Conclusions: Super-obesity in pregnancy in Australia is associated with increased rates of pregnancy and birth complications, and with social disadvantage. There is an urgent need to further address risk factors leading to super-obesity among pregnant women and for maternity services to better address pre-pregnancy and pregnancy care to reduce associated inequalities in perinatal outcomes. Keywords: Super-obesity, Obesity, Perinatal outcomes, Pregnancy, Maternal socio-economic disadvantage, Obstetric complication

Validity of anthropometric regression equations for predicting changes in body fat of obese females

The validity of ten popular anthropometric percent fat prediction equations for estimating changes in percentage of body fat for obese females was studied. Thirty-one obese females (mean ± SEM, %fat = 36.7 ± 1.1%, body mass = 75.6 ± 1.7 kg, age = 32.8 ± 1.1 years) participated in a diet-only, diet-plus-exercise, or exercise-only program. Subjects lost 2.7 ± 0.3 fat percentage points and 3.0 ± 0.3 kg body mass during the 8-week study. While many of the equations had acceptable validity before and after body mass loss, when applied to the prediction of changes in body fat none of the equations was acceptable. It was concluded that use of anthropometric prediction equations to estimate individual percent fat change scores results in large errors and is not recommended.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/38537/1/1310010114_ftp.pd